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Scheltema NM, Gentile A, Lucion F, et al. Rha B, Curns AT, Lively JY, et al. These results were also recently published in The New England Journal of Medicine.
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an artificial heart valve; or
any active bleeding from a surgery, injury, or other cause.
Dabigatran may cause you to bleed more easily, especially if:
you have a stomach ulcer;
you have recent or recurring bleeding in your stomach or intestines;
you have kidney disease (especially if you also take dronedarone or ketoconazole);
you take certain other medicines that can increase bleeding risk, such as aspirin, clopidogrel (Plavix), heparin, prasugrel, warfarin (Coumadin, Jantoven);
you take an NSAID (nonsteroidal anti-inflammatory drug) on a regular basis, such as ibuprofen (Advil, Motrin), naproxen (Aleve), diclofenac, indomethacin, meloxicam, and others; or
you are older than 75.
Dabigatran can cause a very serious blood clot around your spinal cord if you undergo a spinal tap or receive spinal anesthesia (epidural). This type of blood clot could cause long-term paralysis, and may be more likely to occur if:
you have a genetic spinal defect;
you have a spinal catheter in place;
you have a history of spinal surgery or repeated spinal taps;
you have recently had a spinal tap or epidural anesthesia;
you are taking an NSAID--Advil, Aleve, Motrin, and others; or
you are using other medicines to treat or prevent blood clots.
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